Archive for February, 2010
The Vitamin D Newsletter, by John Cannell, MD
February 28th, 2010 | 
Author: This is a periodic newsletter from the Vitamin D Council, a non-profit trying to end the epidemic of vitamin D deficiency. If you want to unsubscribe, go to the end of this newsletter. If you are not subscribed, you can do so on the Vitamin D Council’s website.
A few weeks ago, the British Medical Journal published a remarkable paper, remarkable that it studied more than 500,000 subjects, remarkable that it had 56 (fifty-six) authors, remarkable that it confirmed low vitamin D levels obtained in the past are a risk factor for developing colon cancer in the future. However, the most remarkable part of the paper is that the 46 scientists minimized the true significance of their own research. They found that vitamin A, even in relatively low amounts, appears to thwart vitamin D’s association with reduced rates of colon cancer.
This is a prospective nested case-controlled study, which means it uses subject’s vitamin D blood samples obtained and frozen in the past and then reviews their medical records into the future to see who gets colon cancer, comparing the study subjects to similar members of the group that did not get the illness. Dr. Mazda Jenab and his 45 colleagues from the International Agency for Research on Cancer confirmed that low vitamin D levels are a risk for colon cancer in a dose response manner; those with the highest levels were about twice as less likely to develop colon cancer compared to those with the highest levels.
However, hidden on page eight is one sentence and a small table, which shows that the benefits of vitamin D are almost entirely negated in those with the highest vitamin A intake. And the retinol intake did not have to be that high in these older adults to begin to negate vitamin D’s effects, about 3,000 IU/day. Remember, young autistic children often take 3,500 IU of retinol a day in their powdered multivitamins, which doesn’t count any additional vitamin A given in high single doses.
This is the largest study to date showing vitamin A blocks vitamin D’s effect and explains some of the anomalies in other papers on vitamin D and cancer. For example, Dr. Rachael Stolzenberg-Solomon of the NIH conducted two similar studies on pancreatic cancer, with startling different results. Her first paper showed high vitamin D levels tripled the subsequent risk of pancreatic cancer, her second paper showed no effect. The difference, the first was conducted in a cod liver oil country, Finland, the second in the USA.
Prostate cancer is another good example; ten similar studies have been conducted on vitamin D blood levels and the risk of subsequent prostate cancer. Dr. Lu Yin of the German Cancer Research Center reviewed them in detail. Eight of the studies found no relationship but two studies found a U shaped curve, that is, an increased risk of prostate cancer at both lower and higher vitamin D levels. You guessed it; both of these studies were from Nordic countries where cod liver oil consumption is rampant.
So why is there no relationship between vitamin D levels and the future risk of prostate cancer? All the subjects had their vitamin D levels checked in the late 1980s or 1990s, well into the sun-scare but before the vitamin D revolution. So how did these older people get high levels of vitamin D back then? Multivitamins? No, they only contained a meaningless 400 IU. Vitamin D supplements? No, they were not widely available back then and only contained a meaningless 200 to 400 IU of vitamin D if available. Sunshine? Maybe, but I doubt it. Studies have shown that the elderly were the first to abide by sun-avoidance advice; anyway, the elderly lose the ability to make vitamin D from sunshine; it takes the elderly up to ten times more time in the sun that the young to make an equivalent amount of vitamin D.
However, the elderly of many countries, not just Nordic countries, were raised on cod liver oil and I suspect that a sizable number of Americans continue to take cod liver oil as they age. While cod liver oil from the 1980s and 90s had higher amounts of vitamin D than does modern cod liver oil, it still had toxic amounts of A. I suspect if authors of the above ten studies had controlled for cod liver oil intake, they would have found that high retinol intake was blocking the cancer-preventing effects of vitamin D.
I say this because one author has controlled for retinol intake and the pre-cancerous condition, colon adenomas. Dr. Kyungwon Oh, of the Korea Centers for Disease Control and Prevention, working with Harvard epidemiologists, found that high retinol intake completely thwarted the beneficial effects of vitamin D, stating, “a higher retinol intake, approximately > 4,800 IU/day, appears to counter the beneficial effect of vitamin D . . .” In other words, exactly what the British Medical Journal paper found with colon cancer.
Let”s look at Dr. Pamela Goodwin”s study from the University of Toronto that studied breast cancer survival. This a very different study as it looked at vitamin D levels obtained after the diagnosis of breast cancer and subsequent survival in 535 Toronto women between 1989 and 1996. Vitamin D levels ranged from 3 ng/ml to 70 ng/ml. The women with the lowest levels were about twice as likely to die and to suffer distant cancer recurrence compared those with the highest levels. Ten year survival was 85% for those in the upper one-third of vitamin D levels compared to 74% in the lower one-third. However, the data suggested a U shaped curve for the women with levels above 40 ng/ml, that is, a higher risk of dying, but it was not statistically significant.
Again, let”s ask where women would get levels above 40 ng/ml in Toronto between 1989 and 1996? Sunshine? We know the answer is no as the authors found no seasonal variation in 25(OH)D levels in the 535 women, even in the women with the highest levels. So where did blood levels of 40-70 ng/ml come from in the early 1990s? Vitamin D supplements were not widely available in the early 1990s, and only contained meaningless doses when available. As sunshine was ruled out, they could only have gotten it from cod liver oil. I have emailed Dr. Pamela Goodwin, lead author, asking how hard it would be to see if cod liver oil use was asked about in the dietary questionnaire and if she could control for cod liver oil intake. She did find retinol intake was associated with higher vitamin D levels but I am particularly interested in cod liver oil intake in women with vitamin D levels above 40 ng/ml.
It’s not just in breast cancer that vitamin D levels appear to have a treatment effect; it’s in lung, prostate and colon cancer as well. Again, these are studies of people diagnosed with cancer to see if high vitamin D levels at the time of diagnosis are associated with improved survival.; that is, do high vitamin D levels have a treatment effect? On average, those with the highest vitamin D levels at time of diagnosis lived 2 or 3 times longer. One has to ask how high vitamin D levels are associated with greatly improved survival once you get cancer but a higher risk of getting cancer in the first place. That requires some gymnastic thinking and acrobatic basic science.
Remember, studies of vitamin D levels and subsequent risk of cancer are only one type of epidemiological study. Studies of latitude and cancer are quite clear, the less sunshine the higher the cancer risk. Studies of dietary vitamin D intake and cancer are also mostly supportive but such studies are limited by the tiny doses people get in their diets.
So it is not just autistic children that are being harmed by vitamin A. Avoid cod liver oil like the poison it is and check your multivitamins. Life Extension Foundation just reformulated their multivitamin to contain only 500 IU of preformed retinol. And, I am happy to report that Purity Products, which markets my vitamin D, has no preformed retinol at all in any of their multivitamins, only beta carotene. Purity has also stopped selling cod liver oil. Now, if only Carlson, Solgar, Nature’s Way, and other companies would stop selling cod liver oil and stop selling their concentrated vitamin A supplements to a country whose problem is widespread sub-clinical vitamin A toxicity, I’d be a happier agitator.
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New Tumor Test Tells Whether More Cancer Treatment Is Needed
The test uses a sample of the original tumor to identify unique cancer gene sequences. Later blood tests look for that genetic signature and tell whether surgeons removed the entire tumor, whether the cancer has spread to other parts of the body, or whether the cancer is coming back.
http://www.webmd.com/cancer/news/20100218/new-test-tells-if-cancers-coming-back
Aspirin might reduce recurrence risk for breast cancer survivors
Women who take aspirin regularly after their breast cancer goes into remission are about 50% less likely to suffer a recurrence or to die from the disease, according to new findings from the ongoing Nurses’ Health Study.
Metastasis is clearly linked to inflammation, and aspirin reduces inflammation. Studies in laboratory dishes show that aspirin can inhibit the growth and invasiveness of breast cancer cells and stimulate the immune system to attack the cells.
The study, led by researchers from Brigham and Women’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School and funded by the National Institutes of Health, is the largest to look at whether taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) after breast cancer diagnosis reduces the risk of breast cancer death or distant recurrence.
Homeopathic remedies have a beneficial effect on breast cancer cells
A new study that was just published in the International Journal of Oncology reveals that homeopathic remedies have a beneficial effect on breast cancer cells. The study, which was done in MD Anderson Cancer Center in Houston Texas, shows that certain homeopathic remedies have preferentially elevated cytotoxic (killing) effects on breast adenocarcinoma cells compared with cells derived from normal breast epithelium.
The team of researchers commented that the homeopathic remedies appeared to have similar activity to the activity of paclitaxel (Taxol), the most commonly used chemotherapeutic drug for breast cancer, without the toxic effect on the normal cells.
The experiments were conducted in triplicate and repeated at least twice in each case of remedy. The homeopathic medicines tested included: Carcinosin, 30C; Conium maculatum, 3C; Phytolacca decandra, 200C and Thuja occidentalis, 30C, and the strongest effects were found from Carcinosin and Phytolacca.
The researchers concluded, “the ultra-diluted natural homeopathic remedies investigated in this study offer the promise of being effective preventive and/or therapeutic agents for breast cancer and worthy of further study.”
Homeopathy has been a very controversial system of care, commonly practiced in Europe, but not commonly used in cancer care. This is the first scientific study that investigated the effect of homeopathic remedies on breast cancer cells. This study raises the exciting possibility of a window of therapeutic opportunity for preferentially eliminating breast cancer cells with minimal damage to the surrounding normal mammary tissue by using homeopathic remedies.
This study was wholly supported by internal funds of MD Anderson Cancer Center.
To read more:
Dangers of third-hand smoke revealed
Nicotine in third-hand smoke, the residue from tobacco smoke that clings to virtually all surfaces long after a cigarette has been extinguished, reacts with the common indoor air pollutant nitrous acid to produce dangerous carcinogens. This new potential health hazard was revealed in a multi-institutional study led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab)
Hyperglycemia associated with an increased risk of cancer
European study conducted with more than half a million people, has concluded that there is an increase cancer risk seen with higher blood glucose levels. Dr. Tanja Stocks from Umea University in Sweden and colleagues studied the association between blood glucose and risks of incident and fatal cancer. They concluded that in men, each 1 mmol/L (18 mg/dL) increment in blood glucose level was associated with a 5% increase in incident cancer risk and a 15% increase in fatal cancer risk, and in women, each 1 mmol/L increase in blood glucose level was associated with an 11% increase in incident cancer risk and a 21% increase in fatal cancer risk.
http://www.biooncology.com/bioonc/news-feed/detail.m?id=58236
Omega-3 may reduce risk of Alzheimer’s
The omega-3 compound ethyl-eicosapentaenoic acid (E-EPA) may improve memory and learning, and reduce the risk of Alzheimer´s disease, says a new study.
Researchers from Canada and Thailand report that, while levels of the neurotransmitter acetylcholine decrease with age, E-EPA may slow this decline, according to findings published in the Journal of Neurochemistry.
